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KMID : 0545120100200040817
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Journal of Microbiology and Biotechnology
2010 Volume.20 No. 4 p.817 ~ p.820
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Proteomic analysis of Pancreata from Mini-Pigs treated with Streptozotocin as a Type I Diabetes Models
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Lee Phil-Young
Park Sung-Goo
Kim Eun-Young
Lee Myung-Sup
Chung Sang J.
Lee Sang-Chul
Yu Dae-Yeul
Bae Kwang-Hee
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Abstract
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Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by extreme insulin deficiency due to an overall reduction in the mass of functional pancreatic ?-cells. Several animal models have been used to study T1DM. Among them, mini-pig seems to be a useful model of diabetes because of its similarities in anatomy and physiology to humans. The purpose of this study is to analyze differentially expressed pancreatic proteins in streptozotocin (STZ)-induced mini-pig T1DM model. The pancreas proteins from mini-pigs treated with STZ were separated by 2-dimensional gel electrophoresis and eleven protein spots were found to be altered significantly compared with control mini-pigs. The data in this study from proteomic analysis provide a valuable resource for the further understanding of T1DM pathomechanism.
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KEYWORD
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mini pig, proteomics, streptozotocin, type 1 diabetes mellitus
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